Creamy Chicken Casserole with Cheddar Bay Biscuit Topping

Posted on December 1, 2025

creamy chicken casserole - featured image

Introduction

Let me tell you, this recipe is the ultimate comfort food. It’s creamy, cozy, and topped with flaky, buttery Cheddar Bay biscuits that taste like they came straight from your favorite seafood restaurant. The first time I made this was on a chilly evening when my family was craving something warm and filling. One bite, and we were all hooked. Now, it’s on constant rotation in our house—perfect for busy weeknights or lazy Sundays when you just want to indulge. Trust me, this one’s a keeper.

What makes this creamy chicken casserole shine? It’s the combination of the rich, velvety sauce loaded with tender chicken and veggies, topped with golden, cheesy biscuits that soak up all the delicious flavors. It’s like getting two comfort foods in one dish. And the best part? It’s ridiculously easy to make. I’ll walk you through everything, so you can master this recipe like a pro!

Why You’ll Love This Recipe

Okay, real talk—this is one of those recipes that makes you feel like a kitchen wizard. It’s simple to throw together, but the end result looks and tastes like you spent hours. Here’s why you’ll love it:

Rich and creamy goodness: The sauce is smooth, flavorful, and loaded with chunks of tender chicken and perfectly cooked veggies.
Cheddar Bay biscuit topping: It’s buttery, cheesy, and just the right amount of garlicky. Plus, it bakes up golden and flaky every time.
Perfect for leftovers: This casserole tastes just as good the next day, making it a great option for meal prepping or feeding a crowd.
Easy to customize: Whether you want to swap out veggies or use leftover turkey instead of chicken, this recipe is super forgiving.

Honestly, this is the kind of meal you’ll crave when you’re in need of a food hug. It’s hearty, satisfying, and full of flavor—plus, it’s easy enough for anyone to make. What’s not to love?

What Ingredients You’ll Need

Here’s the thing—I’m all about recipes that use pantry staples and simple ingredients. This creamy chicken casserole is no exception. Let’s break it down:

For the Filling:

Cooked chicken (3 cups / 450g): Shredded or diced. Rotisserie chicken works perfectly, or use leftovers from last night’s roast.
Frozen mixed vegetables (2 cups / 280g): I use a classic mix of peas, carrots, green beans, and corn. No need to thaw—just toss them in.
Cream of chicken soup (1 can / 10.5 oz): This is what makes the filling so creamy. You can use a homemade version if you’re feeling ambitious.
Sour cream (½ cup / 120g): Adds a tangy richness that takes the filling to the next level.
Garlic powder (1 tsp): Because everything tastes better with a hint of garlic.
Salt and pepper: To season the filling to perfection.

For the Cheddar Bay Biscuit Topping:

Biscuit mix (1 package / 11 oz): I use the classic Cheddar Bay biscuit mix you can find at most grocery stores. It’s foolproof.
Shredded cheddar cheese (½ cup / 60g): Adds extra cheesy goodness to the biscuits.
Butter (4 tbsp / 60g): Melted and mixed with the seasoning packet from the biscuit mix for that buttery, garlicky finish.

Quick note: You can swap out the frozen veggies for fresh ones if you prefer, or use cream of mushroom soup instead of chicken soup. This recipe is super flexible, so feel free to make it your own!

Equipment Needed

You don’t need much to make this casserole—just a few kitchen staples:

9×13-inch baking dish: This is your casserole MVP. Glass or ceramic both work great.
Mixing bowls: One for the filling and one for the biscuit topping.
Spatula: For spreading the filling evenly and scraping down bowls.
Whisk: To mix the biscuit batter smoothly.
Oven mitts: Because hot dishes are no joke.

That’s it! No fancy gadgets required. This is a recipe anyone can make with a basic kitchen setup.

How to Make It: Step-by-Step

Ready to make this creamy chicken casserole with Cheddar Bay biscuit topping? Follow these steps—it’s easier than you think!

Preheat your oven to 375°F (190°C). Grease your 9×13-inch baking dish with cooking spray or butter.
Make the filling: In a large mixing bowl, combine the cooked chicken, frozen vegetables, cream of chicken soup, sour cream, garlic powder, salt, and pepper. Stir until everything is evenly mixed. Spread this mixture into your prepared baking dish.
Prepare the biscuit topping: In another bowl, mix the biscuit mix with the shredded cheddar cheese and the amount of water called for on the package instructions. Stir until just combined—don’t overmix! Drop spoonfuls of the biscuit dough evenly over the top of the filling.
Bake: Place the casserole in the oven and bake for 25-30 minutes, or until the biscuits are golden brown and the filling is bubbling around the edges.
Add the butter topping: Once the casserole is out of the oven, mix the seasoning packet from the biscuit mix with melted butter. Brush this over the hot biscuits for that signature Cheddar Bay flavor.
Cool slightly and serve: Let the casserole rest for 5 minutes before digging in—it’ll be easier to scoop, and the flavors will settle.

That’s it! Dinner is served, and your kitchen smells amazing.

My Best Tips & Techniques

After making this casserole more times than I can count, here are my top tips:

Don’t overmix the biscuit dough: Overmixing can make the biscuits tough. Stir just until the ingredients come together, and you’re good to go.
Frozen veggies are your friend: No need to thaw them—they’ll cook perfectly in the oven. Saves time and effort!
Use rotisserie chicken for convenience: It’s already seasoned and perfectly cooked, so it saves a ton of prep time.
Brush the butter topping generously: Don’t skimp on this step—it’s what gives the biscuits their irresistible flavor.
Let it rest before serving: The filling will thicken slightly as it cools, making it easier to serve.

Ways to Mix It Up

If you’re feeling adventurous, here are some fun variations to try:

Buffalo Chicken Version: Add ½ cup buffalo sauce to the filling and sprinkle blue cheese crumbles on top of the biscuits before baking.
Southwest Style: Swap the mixed vegetables for black beans, corn, and diced bell peppers. Add 1 teaspoon chili powder and a pinch of cumin to the filling.
Turkey Casserole: Use leftover turkey instead of chicken—perfect for post-holiday meals.
Vegetarian Option: Skip the chicken and load up on extra veggies like mushrooms, zucchini, and spinach.
Extra Cheesy: Stir ½ cup shredded mozzarella into the filling for even more cheesy goodness.

Make it your own and let me know your favorite twist!

Serving Ideas & Storage

This casserole is a crowd-pleaser, whether you’re serving it for dinner or bringing it to a potluck. Here’s how I like to serve and store it:

Serving Suggestions:

Family Dinner: Serve with a simple green salad or roasted veggies on the side.
Brunch: Pair with scrambled eggs for a hearty weekend brunch.
Potluck Style: This is always a hit—bring it straight in the baking dish for easy transport.

Storage Instructions:

Refrigerator: Store leftovers in an airtight container for up to 4 days. Reheat individual portions in the microwave or the oven.
Freezer: Freeze the casserole (before baking) for up to 3 months. Thaw overnight in the fridge, then bake as directed.

Pro tip: If you have leftover biscuits, they’re amazing warmed up and served with butter or honey!

Nutritional Info & Health Benefits

While this casserole is pure comfort food, it’s also packed with protein and veggies, making it a meal you can feel good about. Here’s the breakdown:

Nutritional Info (per serving)	Amount
Calories	320
Protein	18g
Carbs	35g
Fat	12g
Fiber	3g

It’s filling, satisfying, and a great way to sneak in some veggies!

Final Thoughts

So there you have it—Creamy Chicken Casserole with Cheddar Bay Biscuit Topping! This recipe has quickly become a favorite in my house, and I hope it does the same for you. Whether you’re feeding picky eaters or just craving something warm and comforting, this casserole is the answer.

Make it your own, try out the variations, and let me know how it goes! Drop a comment below, or tag me on Instagram @yourhandle—I love seeing your creations. Happy cooking!

FAQs

Q: Can I use homemade biscuit dough instead of a mix?

A: Absolutely! Just make sure the dough is seasoned well with garlic powder and cheddar cheese to mimic that Cheddar Bay flavor.

Q: Can I make this ahead of time?

A: Yes! Assemble the casserole and refrigerate for up to 24 hours before baking. Add the biscuit topping just before putting it in the oven.

Q: What if I don’t have cream of chicken soup?

A: You can make a quick homemade version by combining chicken broth, milk, and a roux of butter and flour. Or use cream of mushroom soup as a substitute.

Q: Can I use leftover chicken from another recipe?

A: Definitely! This is a great way to repurpose leftover roast chicken or grilled chicken breasts.

Q: Can I use fresh vegetables instead of frozen?

A: Yes, but you’ll need to cook them slightly first since frozen veggies are partially cooked. Sauté your fresh veggies for a few minutes before adding them to the filling.

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